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Cells act like old tape recorders to monitor health
For the first time, cells have been hacked so they resemble tiny analogue tape recorders. It should allow them to get the inside scoop on our bodies in a way that digital cellular recorders can't
Molecular Biology
Source: New Scientist
Posted on: Friday, Nov 14, 2014, 8:11am
Rating: | Views: 1972 | Comments: 0
Research On Cellular Traffic Bags Nobel Awards
Trio of US-based scientists unraveled how cells shuttle compounds to the right place at the right time
Molecular Biology
Source: Science
Posted on: Monday, Oct 07, 2013, 7:29am
Rating: | Views: 1153 | Comments: 0
DNA damage: The dark side of respiration
Adventitious changes in cellular DNA can endanger the whole organism, as they may lead to life-threatening illnesses like cancer. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich now report how byproducts of respiration cause mispairing of subunits in the double helix.
Molecular Biology
Source: Ludwig-Maximilians-Universit�t M�nchen
Posted on: Thursday, May 23, 2013, 1:15pm
Rating: | Views: 2428 | Comments: 0
Out of sync with the world: Body clocks of depressed people are altered at cell level
Every cell in our bodies runs on a 24-hour clock, tuned to the night-day, light-dark cycles that have ruled us since the dawn of humanity. The brain acts as timekeeper, keeping the cellular clock in sync with the outside world so that it can govern our appetites, sleep, moods and much more.
Molecular Biology
Source: University of Michigan Health System
Posted on: Tuesday, May 14, 2013, 8:30am
Rating: | Views: 2357 | Comments: 0
Researchers identify key cellular organelle involved in gene silencing
RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes — from development to physiology to stress response.
Molecular Biology
Source: University of California - Riverside
Posted on: Friday, Apr 26, 2013, 1:30pm
Rating: | Views: 2058 | Comments: 0
Researchers discover that stem cell senescence drives aging
Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor or stem cells -- important for repair and regeneration of skeletal muscle and maintenance of healthy fat tissue -- are subject to cellular senescence,
Molecular Biology
Source: Mayo Clinic
Posted on: Friday, Apr 19, 2013, 12:00pm
Rating: | Views: 3633 | Comments: 0
Genetic master controls expose cancers' Achilles' heel
In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state and identity. Healthy cells employ these super-enhancers to control genes responsible for cellular functions and developmental transitions—
Molecular Biology
Source: Whitehead Institute for Biomedical Research
Posted on: Friday, Apr 12, 2013, 12:45pm
Rating: | Views: 1461 | Comments: 0
Research reveals Rx target for HPV, Hep C and related cancers
New discoveries by a team of scientists at LSU Health Sciences Center New Orleans for the first time reveal the inner workings of a master regulator that controls functions as diverse as the ability of nerve cells to "rewire" themselves in response to external stimuli and the mechanism by which certain viruses hijack normal cellular processes to facilitate their replication that
Molecular Biology
Source: Louisiana State University Health Sciences Center
Posted on: Thursday, Apr 11, 2013, 12:45pm
Rating: | Views: 1408 | Comments: 0
Siberian fossil revealed to be one of the oldest known domestic dogs
Analysis of DNA extracted from a fossil tooth recovered in southern Siberia confirms that the tooth belonged to one of the oldest known ancestors of the modern dog, and is described in research published March 6 in the open access journal PLOS ONE by Anna Druzhkova from the Institute of Molecular and Cellular Biology, Russian Federation, and colleagues from other institutions.
Archaeology
Source: Public Library of Science
Posted on: Thursday, Mar 07, 2013, 2:00pm
Rating: | Views: 2188 | Comments: 0
Scientists find calcium is the initial trigger in our immune response to healing
For the first time scientists studying the cellular processes underlying the body's response to healing have revealed how a flash of calcium is the very first step in repairing damaged tissue. The findings, published in Current Biology, could lead to new therapies that speed up the healing process following injury or surgery.
Immunology
Source: University of Bristol
Posted on: Friday, Feb 15, 2013, 11:15am
Rating: | Views: 1574 | Comments: 0
Link found between insulin sensitivity, cells' powerhouses
If findings of a new study in mice are any indication, it might be possible to fine-tune cellular powerhouses called mitochondria, tweaking one aspect to increase insulin sensitivity, reduce body and fat mass, and even extend life. Exploiting this target could one day lead to novel treatments for type 2 diabetes — an endocrine system disease that affects 8 percent of
Molecular Biology
Source: University of Texas Health Science Center at San Antonio
Posted on: Wednesday, Jan 30, 2013, 10:30am
Rating: | Views: 1185 | Comments: 0
How can evolutionary biology explain why we get cancer?
Over 500 billion cells in our bodies will be replaced daily, yet natural selection has enabled us to develop defenses against the cellular mutations which could cause cancer. It is this relationship between evolution and the body's fight against cancer which is explored in a new special issue of the Open Access journal Evolutionary Applications.
Evolution
Source: Wiley
Posted on: Wednesday, Jan 23, 2013, 11:45am
Rating: | Views: 1197 | Comments: 0
Molecular twist helps regulate the cellular message to make histone proteins
Histone proteins are the proteins that package DNA into chromosomes. Every time the cell replicates its DNA it must make large amounts of newly made histones to organize DNA within the nucleus.
Molecular Biology
Source: University of North Carolina Health Care
Posted on: Friday, Jan 18, 2013, 4:00pm
Rating: | Views: 1214 | Comments: 0
Trapping malaria parasites inside host cell basis for new drugs
One of the most insidious ways that parasitic diseases such as malaria and toxoplasmosis wreak their havoc is by hijacking their host's natural cellular processes, turning self against self. Researchers from the Perelman School of Medicine, University of Pennsylvania and Johns Hopkins University, led by Doron Greenbaum, Ph.D., assistant professor of Pharmacology at Penn, have ident
Molecular Biology
Source: University of Pennsylvania School of Medicine
Posted on: Thursday, Jan 17, 2013, 12:00pm
Rating: | Views: 1169 | Comments: 0
Cellular patterns of development
For a tiny embryo to grow into an entire fruit fly, mouse or human, the correct genes in each cell must turn on and off in precisely the right sequence. This intricate molecular dance produces the many parts of the whole creature, from muscles and skin to nerves and blood.
Molecular Biology
Source: Stowers Institute for Medical Research
Posted on: Friday, Dec 21, 2012, 12:15pm
Rating: | Views: 1151 | Comments: 0
Researchers discover how hepatitis C virus reprograms human liver cells
Hepatitis C virus has evolved to invade and hijack the basic machinery of the human liver cell to ensure its survival and spread. Researchers at the University of North have discovered how hepatitis C binds with and repurposes a basic component of cellular metabolism known as a microRNA to help protect and replicate the virus.
Molecular Biology
Source: University of North Carolina Health Care
Posted on: Wednesday, Dec 19, 2012, 10:30am
Rating: | Views: 1288 | Comments: 0
Activating ALC1: With a little help from friends
Chromatin remodeling—the packaging and unpackaging of genomic DNA and its associated proteins—regulates a host of fundamental cellular processes including gene transcription, DNA repair, programmed cell death as well as cell fate. In their latest study, scientists at the Stowers Institute for Medical Research are continuing to unravel the finicky details of how these architectural
Molecular Biology
Source: Stowers Institute for Medical Research
Posted on: Saturday, Dec 01, 2012, 8:00am
Rating: | Views: 1592 | Comments: 0
Enzyme inhibition protects against Huntington's disease damage in 2 animal models
Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal models of Huntington's disease. The study led by Massachusetts General Hospital (MGH) researchers will appear in the Dec. 27 issue of Cell Reports and is receiving adv
Molecular Biology
Source: Massachusetts General Hospital
Posted on: Friday, Nov 30, 2012, 1:15pm
Rating: | Views: 3998 | Comments: 0
Researchers develop light-based 'remote control' for proteins inside cells
Scientists at Stanford University have developed an intracellular remote control: a simple way to activate and track proteins, the busiest of cellular machines, using beams of light.
Molecular Biology
Source: Stanford University Medical Center
Posted on: Friday, Nov 09, 2012, 2:15pm
Rating: | Views: 1265 | Comments: 0
New finding gives clues for overcoming tamoxifen-resistant breast cancer
A University of Cincinnati (UC) cancer biology team reports new findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease.
Cancer
Source: University of Cincinnati Academic Health Center
Posted on: Monday, Nov 05, 2012, 8:45am
Rating: | Views: 1504 | Comments: 0
Lactation protein suppresses tumors and metastasis in breast cancer
A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton University and highlighted as the cover paper in November issue of Nature Cell Biology.
Cancer
Source: University at Buffalo
Posted on: Thursday, Oct 25, 2012, 11:30am
Rating: | Views: 1230 | Comments: 0
Energy-sensing switch discovery could have broad implications for Biology & Medicine
Biochemists at The Scripps Research Institute (TSRI) have discovered a genetic sequence that can alter its host gene's activity in response to cellular energy levels. The scientists have found this particular energy-sensing switch in bacterial genes, which could make it a target for a powerful new class of antibiotics. If similar energy-sensing switches are also i
Chemistry
Source: Scripps Research Institute
Posted on: Monday, Oct 22, 2012, 10:45am
Rating: | Views: 1167 | Comments: 0
Rethinking toxic proteins on the cellular level
Histones are proteins needed to assemble DNA molecules into chromosomes. They have long represented a classic balancing act in biology; too few histone molecules result in DNA damage, while too many histones are toxic to the cell. New research at the University of Rochester is causing a fundamental shift in the concept of histone balance and the mechanism behind it.
Biochemistry
Source: University of Rochester
Posted on: Friday, Oct 19, 2012, 11:00am
Rating: | Views: 1281 | Comments: 0
Cells control energy metabolism via hedgehog signalling pathway
Cancer, diabetes, and excess body weight have one thing in common: they alter cellular metabolism. Scientists from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and the Medical University of Vienna together with an international research team have jointly resolved a new molecular circuit controlling cellular metabolism.
Molecular Biology
Source: Max-Planck-Gesellschaft
Posted on: Monday, Oct 15, 2012, 10:00am
Rating: | Views: 1266 | Comments: 0
Scientists build the most complex synthetic biology circuit yet
Using genes as interchangeable parts, synthetic biologists design cellular circuits that can perform new functions, such as sensing environmental conditions. However, the complexity that can be achieved in such circuits has been limited by a critical bottleneck: the difficulty in assembling genetic components that don't interfere with each other.
Molecular Biology
Source: Massachusetts Institute of Technology
Posted on: Wednesday, Oct 10, 2012, 4:00pm
Rating: | Views: 1244 | Comments: 0
Hypothesis: Plasma Membrane Vibrations Act As Cellular Heartbeat
Nobody knows how cells co-ordinate the complex activity inside them. But vibrations of the cell membrane could act as a pulse that synchronises the lot, suggests one biologist
Molecular Biology
Source: Technology Review
Posted on: Wednesday, Oct 03, 2012, 8:03am
Rating: | Views: 1252 | Comments: 0
Geometry plays a role in GPCR transmembrane signaling
A recent study in The Journal of General Physiology characterizes the movement of rhodopsin, a GPCR and member of a large family of transmembrane receptors responsible for many cellular responses and involved in many human diseases.
Molecular Biology
Source: Rockefeller University Press
Posted on: Thursday, Sep 27, 2012, 11:15am
Rating: | Views: 1242 | Comments: 0
Cellular eavesdropping made easy
It is much harder to keep up with a conversation in a crowded bar than in a quiet little café, but scientists wishing to eavesdrop on cells can now do so over the laboratory equivalent of a noisy room.
Molecular Biology
Source: European Molecular Biology Laboratory
Posted on: Tuesday, Sep 25, 2012, 11:15am
Rating: | Views: 1146 | Comments: 0
Pollen cells keep memory to control jumping genes
In any living organism, all cells have the same DNA, but each cell's identity is defined by the combination of genes that are turned on or off, any given moment in time. In animals, this cellular memory is erased between generations, so that the new egg has no memory and, as such, has the potential to become any type of cell. In flowering plants, on the contrary, cellular memory passes from genera
Molecular Biology
Source: Instituto Gulbenkian de Ciencia
Posted on: Friday, Sep 21, 2012, 12:45pm
Rating: | Views: 1553 | Comments: 0
New insights on cell competition
Scientists from the Spanish National Cancer Research Centre (CNIO) describe how natural selection also occurs at the cellular level, and how our body's tissues and organs strive to retain the best cells in their ranks in order to fend off disease processes. These results appear this week in the new issue of Cell Reports. The research, carried out in the CNIO, is led by Eduardo Moreno, who i
Molecular Biology
Source: Centro Nacional de Investigaciones Oncologicas (CNIO)
Posted on: Monday, Sep 17, 2012, 8:45am
Rating: | Views: 1123 | Comments: 0
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